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Chatterjee, A. K. Discovery of novel anti-infective agents. Adv Pharmacol 100, 39-117 (2024). https://doi.org/10.1016/bs.apha.2024.05.001

Dayan Elshan, N. G. R. et al. Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead. J Med Chem 67, 2369-2378 (2024). https://doi.org/10.1021/acs.jmedchem.3c01938

Ghorbani, F. et al. Scalable Thiol Reactivity Profiling Identifies Azetidinyl Oxadiazoles as Cysteine-Targeting Electrophiles. Journal of the Americal Chemical Society 146, 32333-32342 (2024). https://doi.org/10.1021/jacs.4c05711

Schultz, P. G. Synthesis at the Interface of Chemistry and Biology. Accounts of Chemical Research 57 (2024). https://doi.org/10.1021/acs.accounts.4c00320

Shao, S. et al. Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair. Proc Natl Acad Sci U S A 121, e2400077121 (2024). https://doi.org/10.1073/pnas.2400077121

Caldwell N, Afshar R, Baragana B, et al. Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022, ACS Infect Dis. 2023; 9: 1046-55. https://doi.org/10.1021/acsinfecdis.3c00081

Cardoza S, Shrivash MK, Riva L, et al. Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C-1′ Position, J Org Chem. 2023; 88: 9105-22. https://doi.org/doi:10.1021/acs.joc.3c00754

Carucci M, Duez J, Tarning J, et al. Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening, Nat Commun. 2023; 14: 1951. https://doi.org/10.1038/s41467-023-37359-2

Grzelak EM, Elshan N, Shao S, et al. Pharmacological YAP activation promotes regenerative repair of cutaneous wounds, Proc Natl Acad Sci U S A. 2023; 120: e2305085120. https://doi.org/10.1073/pnas.2305085120

Jo J, Kim J, Ibrahim L, et al. Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators, Bioorg Med Chem Lett. 2023; 89: 129306. https://doi.org/10.1016/j.bmcl.2023.129306

Kawata M, McClatchy DB, Diedrich JK, et al. Mocetinostat activates Kruppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis, JCI Insight. 2023; 8. https://doi.org/10.1172/jci.insight.170513

Ko Y, Hong M, Lee S, et al. S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling, Proc Natl Acad Sci U S A. 2023; 120: e2300763120. https://doi.org/10.1073/pnas.2300763120

Lee S, Love MS, Modukuri R, et al. Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition, Bioorg Med Chem Lett. 2023; 90: 129328. https://doi.org/10.1016/j.bmcl.2023.129328

Maher SP, Bakowski MA, Vantaux A, et al. A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites, bioRxiv. 2023. https://doi.org/10.1101/2023.01.31.526483

Oh CK, Nakamura T, Beutler N, et al. Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection, Nat Chem Biol. 2023; 19: 275-83. https://doi.org/10.1038/s41589-022-01149-6

Metaferia B, Cellmer T, Dunkelberger EB, et al. Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease, Proc Natl Acad Sci U S A. 2022; 119: e2210779119. https://doi.org/10.1073/pnas.2210779119

Michaels SA, Hulverson MA, Whitman GR, et al. Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy, Antimicrob Agents Chemother. 2022; 66: e0001722. https://doi.org/10.1128/aac.00017-22

Wilburn KM, Montague CR, Qin B, et al. Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis. PLoS Pathog. Feb 2022;18(2):e1009862. https://doi.org/10.1371/journal.ppat.1009862

Shalhout SZ, Yang P-Y, Grzelak EM, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nature Chemical Biology. 2021;17:767-775. https://doi.org/10.1038/s41589-021-00755-0

Love MS, McNamara CW. Phenotypic screening techniques for Cryptosporidium drug discovery. Expert Opin Drug Discov. Jan 2021;16(1):59-74. https://doi.org/10.1080/17460441.2020.1812577

Lee SC, Ma JSY, Kim MS, et al. A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Sci Adv. Aug 2021;7(33) https://doi.org/10.1126/sciadv.abi8193

Bakowski MA, Beutler N, Wolff KC, et al. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nature Communcations. 2021;12(3309) https://doi.org/10.1038/s41467-021-23328-0

Olson KE, Namminga KL, Schwab AD, et al. Neuroprotective Activities of Long-Acting Granulocyte-Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice. Neurotherapeutics. Oct 2020;17(4):1861-1877. https://doi.org/10.1007/s13311-020-00877-8

Olson KE, Namminga KL, Schwab AD, et al. Neuroprotective Activities of Long-Acting Granulocyte-Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice. Neurotherapeutics. Oct 2020;17(4):1861-1877. https://doi.org/10.1007/s13311-020-00877-8

Chin EN, Yu C, Vartabedian VF, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. Aug 21 2020;369(6506):993-999. https://doi.org/10.1126/science.abb4255

Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020;8(4):472. https://doi.org/10.3390/microorganisms8040472

Roquero I, Cantizani J, Cotillo I, et al. Novel chemical starting points for drug discovery in leishmaniasis and Chagas disease. Int J Parasitol Drugs Drug Resist. Aug 2019;10:58-68. https://doi.org/10.1016/j.ijpddr.2019.05.002

Yang PY, Zou H, Lee C, et al. Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. J Med Chem. Apr 12 2018;61(7):3218-3223. https://doi.org/10.1021/acs.jmedchem.7b00768

Miglianico M, Eldering M, Slater H, et al. Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases. Proc Natl Acad Sci U S A. Jul 17 2018;115(29):E6920-E6926. https://doi.org/10.1073/pnas.1801338115

Janes J, Young ME, Chen E, et al. The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(42):10750-10755. https://doi.org/10.1073/pnas.1810137115

Bollong MJ, Yang B, Vergani N, et al. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. Proc Natl Acad Sci U S A. May 2 2017;114(18):4679-4684. https://doi.org/10.1073/pnas.1702750114

Yang PY, Zou H, Chao E, et al. Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery. Proc Natl Acad Sci U S A. Apr 12 2016;113(15):4140-5. https://doi.org/10.1073/pnas.1601653113

Rodgers DT, Mazagova M, Hampton EN, et al. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. Proc Natl Acad Sci U S A. Jan 26 2016;113(4):E459-68. https://doi.org/10.1073/pnas.1524155113

Liu T, Fu G, Luo X, et al. Rational design of antibody protease inhibitors. J Am Chem Soc. Apr 1 2015;137(12):4042-5. https://doi.org/10.1021/ja5130786

Johnson K, Zhu S, Tremblay MS, et al. A stem cell-based approach to cartilage repair. Science. May 11 2012;336(6082):717-21. https://doi.org/10.1126/science.1215157